Evidence map›Paper›PMID 41211661›Full record

ReviewFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025

Advances in Inhaled Nanoparticle Drug Delivery for Pulmonary Disease Management.

Yunzhou Fan, Yuefang Zhou, Jing Zhao, Yutong Zhao

Abstract readReview
In one paragraph

Review in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Nanozyme-Driven Ferroptosis-Cuproptosis Interplay in Lung Cancer.International journal of nanomedicine · 2026
    Review
  10. Advances in Inhaled Nanoparticle Drug Delivery for Pulmonary Disease Management.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yunzhou FanDepartment of Physiology and Cell Biology, College of Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.
Yuefang ZhouDepartment of Physiology and Cell Biology, College of Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.
Jing ZhaoDepartment of Physiology and Cell Biology, College of Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.ORCID https://orcid.org/0000-0002-0211-9289
Yutong ZhaoDepartment of Physiology and Cell Biology, College of Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.ORCID https://orcid.org/0000-0001-6604-9315

Funding

Molecular regulation of immunoproteasome assembly in inflammatory diseasesR01HL167846 · NHLBI · OHIO STATE UNIVERSITY · PI JING ZHAO · 2023 to 2026
$2.4M
ISGylation regulates lung endothelial inflammationR01HL157164 · NHLBI · OHIO STATE UNIVERSITY · PI ZHAO, YUTONG · 2021 to 2024
$2.2M
Molecular regulation of BMPRII stability in lung fibrosisR01HL169203 · NHLBI · OHIO STATE UNIVERSITY · PI Yutong Zhao · 2023 to 2026
$2.0M
Deubiquitinating and inhibiting Hsp90 by USP40 mitigates lung injuryR01HL151513 · NHLBI · OHIO STATE UNIVERSITY · PI ZHAO, JING · 2020 to 2023
$1.7M
Mitochondrial deubiquitinase USP30 regulates cell metabolism-mediated miRNA biogenesis and microvascular inflammationR01HL171220 · NHLBI · OHIO STATE UNIVERSITY · PI Yutong Zhao · 2025 to 2026
$1.4M
HHS|NIH|National Heart, Lung, and Blood Institute (NHLBI) R01HL151513HHS|NIH|National Heart, Lung, and Blood Institute (NHLBI) R01HL157164HHS|NIH|National Heart, Lung, and Blood Institute (NHLBI) R01HL167846HHS|NIH|National Heart, Lung, and Blood Institute (NHLBI) R01HL169203HHS|NIH|National Heart, Lung, and Blood Institute (NHLBI) R01HL171220NHLBI NIH HHS R01 HL151513NHLBI NIH HHS R01 HL157164NHLBI NIH HHS R01 HL167846NHLBI NIH HHS R01 HL169203NHLBI NIH HHS R01 HL171220
6 · The paper itself

Abstract

Pulmonary disorders, notably highlighted by the global impact of COVID-19, continue to pose serious public health concerns with limited treatment options. To address the urgent need for effective lung-targeted therapies, strategies that maximize local therapeutic efficacy while minimizing systemic toxicity are essential to the unique anatomical location of the lungs, inhaled therapy provides a promising strategy for locally targeted drug delivery through intranasal or intratracheal administration. Integrating biomedical nanotechnology and inhaled therapy, inhaled nanoparticle drug delivery systems (INDDs) have emerged as a powerful platform capable of penetrating mucus and pulmonary surfactant barriers, enhancing lung distribution and retention, and precisely delivering small molecules, proteins, and nucleic acids in lung lesions and cells using natural or synthetic carriers. The INDDs provide a universal translational platform for structurally analogous drugs and a wide array of respiratory disorders. This review summarizes recent advances in INDDs, focusing on the critical carrier materials in formulation, performance in in vitro and in vivo, and inhalation dosage forms, highlighting design strategies to overcome lung barriers and improve clinical and preclinical therapeutic efficacy in lung diseases.

Indexed as

COVID-19 Drug TreatmentDrug Delivery SystemsLung DiseasesNanoparticle Drug Delivery SystemNanoparticlesAdministration, InhalationAnimalsCOVID-19HumansLungSARS-CoV-2Nanoparticle Drug Delivery SystemCOVID‐19inhalationintratrachealnanoparticlerespiratory disease

Identifiers

PMID41211661
PMCPMC12598920

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.