Study of Batch and Semibatch Reactive Crystallization of l‑Glutamic Acid with aid of PATs, focusing on Polymorphism and Crystal Habit.

Biyu Zhang, Christos Xiouras, Merve Öner, Georgios D Stefanidis, Tom Van Gerven

Abstract read

In one paragraph

Article in Crystal growth & design, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Evaluation of Nucleation and Growth Kinetics of LiMolecules (Basel, Switzerland) · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Biyu ZhangDepartment of Chemical Engineering, Process Engineering for Sustainable Systems, KU Leuven, Celestijnenlaan 200F, Leuven 3001, Belgium.ORCID https://orcid.org/0000-0002-3963-3900

Christos XiourasJanssen Research and Development, Janssen Pharmaceutical Companies of Johnson & Johnson, Turnhoutseweg 30, Beerse 2340, Belgium.ORCID https://orcid.org/0000-0001-7162-234X

Merve ÖnerJanssen Research and Development, Janssen Pharmaceutical Companies of Johnson & Johnson, Turnhoutseweg 30, Beerse 2340, Belgium.

Georgios D StefanidisSchool of Chemical Engineering, Department of Process Analysis and Plant Design, National Technical University of Athens, Iroon Polytecneiou 9, Zografou, Athens 15780, Greece.ORCID https://orcid.org/0000-0002-4347-1350

Tom Van GervenDepartment of Chemical Engineering, Process Engineering for Sustainable Systems, KU Leuven, Celestijnenlaan 200F, Leuven 3001, Belgium.ORCID https://orcid.org/0000-0003-2051-5696

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This work investigates the reactive crystallization of l-glutamic acid under different supersaturation generation strategies. Using PATs such as ATR-FTIR and in situ microscopes enables real-time monitoring of the supersaturation trajectory as well as the nucleation and growth behavior. In the batch process, crystallization starts instantaneously after the acid is added, leading to fines and clusters in the final products. Conversely, in the semibatch process, acid is dosed continuously, and more uniform α-LGA crystals are produced. The stochastic induction points were between the supersaturation range S

Identifiers

PMID41211600

DOI10.1021/acs.cgd.5c01005

PMCPMC12593399

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.