ArticleBioactive materials2026
Biomineralization-inspired scaffolds using citrate-based polymers to stabilize amorphous calcium phosphate promote osteogenesis and angiogenesis for bone defect repair.
Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- Defect-Mediated Sonodynamic Catalysis on Calcium-Deficient Hydroxyapatite Nanoparticles Coordinating Bacterial Elimination and Bone Regeneration against Osteomyelitis.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- A continuous adhesion-enhanced osteogenic pathway in artificial scaffold drives cellular infiltration and condensed mineralization for rapid bone regeneration.Bioactive materials · 2026Article
- Preparation of amorphous calcium phosphate nanoparticles using small organic molecules for biomimetic mineralization of dentin.RSC advances · 2026Article
- Adipose Tissue Engineering Biomaterials: Smart Scaffolds, Vascularization, and Clinical Frontiers.Biomolecules · 2026Review
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14 authors.
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Abstract
Bone defect repair requires bone mineralization, during which amorphous calcium phosphate (ACP) plays a critical role in the formation and phase transformation of bone apatite. ACP-based biomaterials continuously release calcium and phosphate, promoting the deposition and maturation of bone minerals. This effectively overcomes the limitations of insufficient osteoinductivity of crystalline calcium phosphate (CaP) phases such as hydroxyapatite (HA). However, the instability of ACP leads to its spontaneous conversion into stable CaP phases, reducing its inherent osteogenic potential. Therefore, stabilizing ACP to maintain its bioactivity is crucial for bone repair biomaterials. Inspired by the bone biomineralization and the natural stabilization of ACP by citrate in bone, we developed a porous biomimetic mineralized scaffold (POC-ACP) using citrate-based poly (octamethylene citrate) (POC) to stabilize ACP for bone defect repair. The stabilized ACP acted as a mineralization seed, initiating the bone mineralization process and promoting new bone formation. Meanwhile, its excellent mechanical and porous structure supported cell and tissue ingrowth. Compared to the POC-HA scaffold, the POC-ACP scaffold significantly enhanced osteogenesis and angiogenesis both
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