ArticleOsteoarthritis and cartilage open2025
Comparison of three different therapeutic interventions in the management of knee osteoarthritis: Randomized controlled parallel group pilot trial.
Article in Osteoarthritis and cartilage open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05636059 (Comparative Effects of Different Physiotherapy Methods on Pain, Function and Quality of Life in Patients With Knee Osteoarthritis), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparative Effects of Different Physiotherapy Methods on Pain, Function and Quality of Life in Patients With Knee Osteoarthritis
Who cites it
1 citing paper in PubMed.
- Role of external forces in the mechanobiology of stem and differentiated chondrogenic cells embedded in a tissue-engineered construct for cartilage repair.Journal of biomedical science · 2026Review
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The study aimed to compare the effectiveness of different physical interventions on pain intensity, knee function, and quality of life in patients with knee osteoarthritis (OA). Methods: This pilot trial involved 63 patients (45-55 yrs) in a rehabilitation center. Patients were randomly assigned to three groups: therapeutic exercise alone (TE, n = 21), TE and cryotherapy (TE-Cr, n = 21), and TE and joint mobilization (TE-JM, n = 21). The primary outcome was pain intensity, secondary outcomes included knee joint function (WOMAC), muscle strength, knee joint range of motion (ROM), and quality of life (SF-36). Data were collected at baseline and after 18 days of inpatient rehabilitation. Results: There were no significant between-group differences in the primary outcome at baseline. After 18 days, all intervention groups showed significant improvements (p < 0.05). The TE-JM group reported lower (p < 0.05) pain levels (3.24 ± 1.04) compared to the TE-only (4.76 ± 0.77) and TE-Cr (4.86 ± 0.57) groups. The TE-Cr group had a lower (p < 0.05) SF-36 total score (52.81 ± 10.50) than the TE (62.00 ± 9.74) and TE-JM (66.62 ± 2.87) groups. No significant between-group differences were observed in ROM or muscle strength. The WOMAC total score was lower (p < 0.05) in the TE-JM group (27.3 ± 13.9) compared to the TE-Cr group (40.1 ± 10.7). Conclusion: Although all three interventions had beneficial short-term effects, leading to reductions in knee pain and improvements in physical function and quality of life, but no single intervention demonstrated superior effectiveness across all assessed outcomes. Trial registration: ClinicalTrials.gov, http://www.clinicaltrials.gov, NCT05636059.
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