ArticleHealth science reports2025
Investigating the Associated Factors of Mood Disorders and Fatigue in Multiple Sclerosis Patients With Cognitive Impairment: A Cross-Sectional Study.
Article in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Running out the clock: Circadian rhythm dysfunction in cognitive disease.International review of neurobiology · 2026Review
- Agitation, Alzheimer's disease, and autophagy: mechanistic insights into aging pathways, gut microbiome, and artificial intelligence.Frontiers in immunology · 2026Review
- Investigating the Associated Factors of Mood Disorders and Fatigue in Multiple Sclerosis Patients With Cognitive Impairment: A Cross-Sectional Study.Health science reports · 2025Article
- Dementia, mood disorders, and aging: Bridging new avenues of care through shared biological pathways.Aging advancesArticle
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: This study aimed to investigate the factors associated with mood disorders and fatigue in multiple sclerosis patients with cognitive impairment. Methods: This cross-sectional study included 70 out of 155 MS patients exhibiting cognitive impairment (CI) from a referral clinic in Kerman, Iran, between 2023 and 2024. The Persian-adapted Brief International Cognitive Assessment for MS (BICAMS) tests, which include the California Verbal Learning Test (CVLT-II) to assess auditory or verbal episodic memory, the Symbol Digit Modalities Test (SDMT) to assess visual processing speed and working memory have been used. Independent Results: Out of 70 patients, 61 (87.1%) were women. The most frequently reported symptoms were fatigue and mood disorders. The mean of BICAMS domains in patients with CI was significantly lower than in non-CI patients ( Conclusion: Information processing speed and working memory were the most affected cognitive domains in MS patients. Furthermore, mood disorders were more prevalent in older patients and those with higher EDSS, while fatigue was more pronounced in women and those with higher EDSS. Therefore, it is of higher importance to address the issue of CI and its association with fatigue and depression, particularly in the Iranian people.
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