ArticleMediators of inflammation2025
A Multitrait Analysis of Genome-Wide Association Study Reveals the Shared Genetic Architecture Between Inflammatory Bowel Disease and Ankylosing Spondylitis.
Article in Mediators of inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Severe Pancolitis Presenting with Sacroiliitis: A Case Report Highlighting the Gut-Joint Axis in Ulcerative Colitis.Case reports in gastroenterologyArticle
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Authors and funding
5 authors.
Funding
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Abstract
Background: Clinical evidence indicates that inflammatory bowel disease (IBD) and ankylosing spondylitis (AS) often co-occur, but their genetic mechanisms remain unclear. Our objective is to explore the genetic relationship between IBD and AS. Methods: Using large-scale summary statistics from genome-wide association study (GWAS), we investigated the shared genetic architecture between IBD, including ulcerative colitis (UC) and Crohn's disease (CD), and AS. Starting with genetic correlation, we then examined shared genetic structures and genes, followed by causal inference, and explored potential functional genes and biological pathways in tissue and cell types. Results: We observed a positive genetic correlation between IBD and AS (IBD-AS: Conclusions: This study confirms the genetic correlation between IBD and AS, identifies their shared genetic architecture and biological pathways, providing strong evidence for the genetic comorbidity of IBD and AS. These findings offer directions for future research.
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