ArticleFrontiers in oncology2025
Combined assessment of inflammation and food intake contributes to prognostic stratification of gastric cancer.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Lymphocyte-to-C-reactive protein ratio as a clinically feasible nutrition-inflammation marker for predicting outcomes in patients with gastric cancer.Oncology letters · 2026Article
- Comment on "Prognostic Value of Pretreatment C-Reactive-Protein-Albumin-Lymphocyte Index in Colorectal Cancer: Systematic Review and Meta-Analysis".Journal of gastrointestinal cancer · 2026Article
- Development and validation of a novel prognostic model for gastric signet ring cell carcinoma based on inflammation-nutrition indicators.Frontiers in nutrition · 2026Article
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Authors and funding
9 authors.
Funding
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Abstract
Background: Patients with gastric cancer (GC) present with chronic inflammation and malnutrition risk. Lymphocyte-to-C-reactive protein ratio (LCR) and food intake are promising indicators for predicting inflammatory and nutritional states. Methods: This multi-center cohort study included 763 patients with GC. Time-dependent receiver operating characteristic curves were generated to determine the prediction accuracy of 16 systemic inflammatory indicators. Association of the model constructed by LCR and food intake with overall survival (OS) were analyzed using the Kaplan-Meier method and Cox regression model. Results: In this analysis, patients with reduced food intake accounted for 60.4%. The area under the curve and C-index of LCR for all-cause mortality were higher than those of the other indicators in patients with GC and there was a significant inverse relationship between LCR and all-cause mortality (per SD increment HR: 0.79, 95% CI: 0.65-0.96; Conclusions: Combined assessment of inflammation and food intake contributes to prognostic stratification of GC. Active therapeutic measures to reduce inflammation and increase nutrition may improve outcomes of affected patients.
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