Evidence map›Paper›PMID 41211304›Full record

ArticleNeurobiology of pain (Cambridge, Mass.)

Brain aging among individuals with trigeminal neuralgia.

Yenisel Cruz-Almeida, Pedro A Valdes-Hernandez, Yun Liang, Mingzhou Ding, John K Neubert

Abstract read
In one paragraph

Article in Neurobiology of pain (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yenisel Cruz-AlmeidaPain Research & Intervention Center of Excellence, University of Florida, Gainesville, FL, United States.
Pedro A Valdes-HernandezPain Research & Intervention Center of Excellence, University of Florida, Gainesville, FL, United States.
Yun LiangDepartment of Biomedical Engineering, University of Florida, Gainesville, FL, United States.
Mingzhou DingDepartment of Biomedical Engineering, University of Florida, Gainesville, FL, United States.
John K NeubertDepartment of Biomedical Sciences, College of Dentistry, Texas A&M University, Dallas, TX, United States.

Funding

Machine learning-based brain aging morphological signatures of chronic musculoskeletal painK01AG083228 · NIA · UNIVERSITY OF FLORIDA · PI Pedro Antonio Valdes Hernandez · 2024 to 2026
$379k
NIA NIH HHS K01 AG083228
6 · The paper itself

Abstract

Trigeminal neuralgia (TN) is a complex orofacial neuropathic pain condition with limited understanding of underlying mechanisms and therapeutic options. Emerging evidence suggests the involvement of the brain in persons with TN including widespread brain changes when employing a widely used brain aging biomarker that estimates a predicted brain age difference or brain age gap. The aim of the present cross-sectional study was to assess the predicted brain age difference (brain-PAD) or brain age gap across two TN subtypes (classical TN, and secondary/idiopathic TN) in comparison with age-and sex-matched pain-free controls and its association with several clinical and psychological characteristics. Thirty-four individuals diagnosed with Classical TN, 17 diagnosed with secondary/idiopathic TN were age- and sex-matched to pain-free controls (n = 54). All participants underwent a T1 brain MRI and completed clinical and psychological measures. There were significant differences in brain-PAD among TN subtypes (ANCOVA p = 0.0078, effect size f

Indexed as

AgingBrainBrain ageBrain age gapPainTrigeminal neuralgia

Identifiers

PMID41211304
PMCPMC12593668

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.