Evidence map›Paper›PMID 41211282›Full record

ArticleFrontiers in neurology2025

Iron chelation as a therapeutic target in vanadium neurotoxicity and Parkinson's disease: role of medicinal plants.

Francis Olaolorun, Melanie-Jayne R Howes, Taiwo Elufioye, Oluwatoyin A Odeku, James Olopade, Paul Chazot

Abstract read
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In one paragraph

Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Francis OlaolorunNeuroscience Unit, Department of Veterinary Anatomy, University of Ibadan, Ibadan, Nigeria.
Melanie-Jayne R HowesRoyal Botanic Gardens Kew, Richmond, United Kingdom.
Taiwo ElufioyeDepartment of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria.
Oluwatoyin A OdekuDepartment of Pharmaceutics and Industrial Pharmacy, University of Ibadan, Ibadan, Nigeria.
James OlopadeNeuroscience Unit, Department of Veterinary Anatomy, University of Ibadan, Ibadan, Nigeria.
Paul ChazotDepartment of Biosciences, Durham University, Durham, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bioprospecting plant natural products has yielded significant success in the development of symptomatic treatment of neurodegenerative diseases, including the two most common, Alzheimer's and Parkinson's diseases (PD). Dysregulation of iron has been strongly implicated in the pathophysiology of these serious intractable diseases. A series of Nigerian endemic plants' methanolic extracts were explored using a Ferrozine binding iron chelation assay. This identified

Indexed as

Drosophilairon homeostasisoxidative stressParkinson's diseasePINK-1Spondias

Identifiers

PMID41211282
PMCPMC12591949

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.