ArticleFrontiers in nutrition2025
Pre-operative habitual dietary fibre stratifies 12-week immune-inflammatory recovery after oesophagectomy: a multicentre prospective cohort study.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: To test whether habitual pre-operative dietary fibre predicts 12-week immune-inflammatory recovery after oesophagectomy. Methods: We conducted a multicentre prospective cohort across three tertiary hospitals. Adults with resectable oesophageal cancer completed a validated FFQ; total fibre (energy-adjusted) was grouped into sex-specific quartiles. Prespecified week-12 endpoints were: (i) a favourable inflammatory profile (CRP within reference or ≥50% fall plus NLR ≤ 3.0) and (ii) lymphocyte recovery (≥30% rise or ≥1.5 × 10^9·L Results: Among 312 participants, event rates increased monotonically with higher fibre. Versus Q1, adjusted RRs for the favourable inflammatory profile were 2.36 (1.85-3.01) in Q3 and 2.62 (2.20-3.12) in Q4; for lymphocyte recovery, 1.63 (1.39-1.92) and 1.79 (1.65-1.95), respectively. Each +10 g·day Conclusion: Higher habitual fibre before surgery was associated with materially better week-12 immune-inflammatory recovery after oesophagectomy, with consistent dose-response and longitudinal signals across centres. Routine pre-operative fibre appraisal offers a low-cost, clinic-ready stratifier for counselling and prehabilitation; interventional studies should test whether augmenting habitual fibre improves recovery trajectories.
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