ArticleCardiac failure review2025
Prevalence and Prognostic Significance of Malnutrition Assessed by Two Scoring Systems in Hospitalised Elderly Patients with Chronic Heart Failure.
Article in Cardiac failure review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed.
- Albumin-based nutritional-inflammatory indices and prognosis in critically ill patients with acute myocardial infarction: a MIMIC-IV cohort study.BMC cardiovascular disorders · 2026Article
- Muscle and Bone Implications of GLP-1 Receptor Agonists and Fragility Fractures in Older Adults With Diabetes.Journal of cachexia, sarcopenia and muscle · 2026Article
- Association between prognostic nutritional index and mortality in critically ill patients with atrial fibrillation: a retrospective cohort study.BMC cardiovascular disorders · 2026Article
- Association of malnutrition with in-hospital outcomes among patients hospitalized with dermatomyositis or polymyositis.Clinical rheumatology · 2026Article
- Determinants and Prognostic Impact of In-Hospital Sodium-Glucose Cotransporter-2 Inhibitor Initiation in Patients with Heart Failure.Clinical drug investigation · 2026Observational
- Prognostic Role of Immunonutritional Indices in Elderly Patients with HFpEF: Long-Term Follow-Up of the CONUT, PNI, and CALLy Scores.Journal of clinical medicine · 2026Article
- Dynamic association between triglyceride-glucose-body mass index and hospital mortality in critically ill patients with heart failure: a multicenter retrospective cohort study.Cardiovascular diabetology · 2026Observational
- Prevalence and associated factors of frailty in hospitalized elderly patients with heart failure.Frontiers in cardiovascular medicine · 2026Article
- Obesity Definitions and Hospital Stay in Older Adults with Heart Failure: A Post Hoc Analysis of a Prospective Cohort.Cardiac failure review · 2026Article
- Nutritional and inflammatory biomarkers predicting hospitalization length in acute decompensated heart failure EF below 50.Frontiers in cardiovascular medicine · 2026Article
- Clinical implications of malnutrition in Huntington's disease progression: evidence from a Chinese cohort and Mendelian randomization.Frontiers in nutrition · 2026Article
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9 authors.
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Abstract
Background: Malnutrition is common yet underrecognised in elderly patients (≥65 years) with chronic heart failure (CHF) and may accelerate disease progression through cytokine activation, autonomic dysfunction and cachexia. Early identification may improve risk stratification, but standardised diagnostic criteria are lacking. Inflammatory markers such as high-sensitivity C-reactive protein (hsCRP) and soluble urokinase plasminogen activator receptor (suPAR) may influence both the presence and prognostic implications of malnutrition, but their interaction with nutritional indices remains poorly understood. This study examined the prevalence and prognostic significance of malnutrition using Prognostic Nutritional Index (PNI) and Geriatric Nutritional Risk Index (GNRI). Methods: From 10,027 consecutive admissions, 597 elderly patients with CHF were included. Nutritional status was assessed using PNI and GNRI. Patients meeting either the PNI or GNRI criteria for moderate or severe malnutrition were classified as malnourished; others were considered well-nourished. One-year all-cause mortality was evaluated using Cox regression models. Predictive performance was assessed using receiver operating characteristic analysis and DeLong's test. Results: Moderate or severe malnutrition was identified in 42.2% using the PNI and in 31.2% using the GNRI. Severe malnutrition was independently associated with higher 1-year mortality (PNI: HR 1.43, p=0.038; GNRI: HR 1.78, p=0.043). GNRI showed better post-discharge discrimination (AUC 0.666 versus 0.586, p=0.002). Prognostic value of both indices varied by BMI and inflammation. GNRI-defined malnutrition showed significant interaction with hsCRP and suPAR. Conclusion: In elderly CHF patients, malnutrition was common and independently associated with mortality. Prognostic value varied by BMI and inflammation, with GNRI showing enhanced discriminatory ability. In acute care settings, PNI and GNRI may aid nutritional risk stratification.
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