Evidence map›Paper›PMID 41211168›Full record

ArticleFood science & nutrition2025

Causal Influences of Micronutrients on Anxiety: Insights From an Observational and Mendelian Randomization Analysis.

Xinyu Fang, Qian Zhao, Peizi Liu, Ancha Baranova, Hongbao Cao, Xiangrong Zhang, Fuquan Zhang

Abstract read
In one paragraph

Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xinyu FangDepartment of Geriatric Psychiatry The Affiliated Brain Hospital of Nanjing Medical University Nanjing China.ORCID https://orcid.org/0000-0002-3503-7765
Qian ZhaoDepartment of Psychiatry The Affiliated Brain Hospital of Nanjing Medical University Nanjing China.
Peizi LiuDepartment of Psychiatry The Affiliated Brain Hospital of Nanjing Medical University Nanjing China.
Ancha BaranovaSchool of Systems Biology George Mason University Fairfax USA.
Hongbao CaoSchool of Systems Biology George Mason University Fairfax USA.ORCID https://orcid.org/0000-0001-6591-9518
Xiangrong ZhangDepartment of Geriatric Psychiatry The Affiliated Brain Hospital of Nanjing Medical University Nanjing China.ORCID https://orcid.org/0000-0002-2737-2168
Fuquan ZhangDepartment of Psychiatry The Affiliated Brain Hospital of Nanjing Medical University Nanjing China.ORCID https://orcid.org/0000-0003-3204-8191

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An increasing number of studies have begun to focus on the role of micronutrients (vitamins and minerals) in mental disorders, including anxiety. Previous observational and clinical studies have suggested a relationship between micronutrients and anxiety, yet the causal link between them remains unclear. We aimed to detect the potential causal relationships between genetically predicted supplementation with vitamins (including vitamins A, B, B6, B12, C, D, E, folate, and multivitamins), minerals (including calcium, iron, magnesium, selenium, and zinc), and anxiety through Mendelian randomization (MR) analysis, the Bayesian colocalization analysis, and real-world observational data. Summary genome-wide association study datasets covering various supplements from the UK Biobank (

Indexed as

anxietymendelian randomizationmicronutrientsmineralsvitamins

Identifiers

PMID41211168
PMCPMC12588952

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.