Evidence map›Paper›PMID 41211066›Full record

ArticleOpen life sciences2025

PSME2 exacerbates ulcerative colitis by disrupting intestinal barrier function and promoting autophagy-dependent inflammation.

Min Li, Jing Chen, Shimeng Xu, Zhaoxiu Liu, Cuihua Lu, Sijia Ge

Abstract read
In one paragraph

Article in Open life sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Min LiAffiliated Hospital of Nantong University, Nantong University, Nantong, Jiangsu, 226001, China.
Jing ChenAffiliated Hospital of Nantong University, Nantong University, Nantong, Jiangsu, 226001, China.
Shimeng XuAffiliated Hospital of Nantong University, Nantong University, Nantong, Jiangsu, 226001, China.
Zhaoxiu LiuAffiliated Hospital of Nantong University, Nantong University, Nantong, Jiangsu, 226001, China.
Cuihua LuAffiliated Hospital of Nantong University, Nantong University, Nantong, Jiangsu, 226001, China.
Sijia GeAffiliated Hospital of Nantong University, Nantong University, Nantong, Jiangsu, 226001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The immunoproteasome regulatory component proteasome activator subunit beta (PSME2) plays a crucial role in immune regulation, yet its impact on intestinal barrier integrity in ulcerative colitis (UC) remains unclear. This study aimed to elucidate the involvement of PSME2 in UC pathogenesis. Clinical samples from UC patients and healthy controls were analyzed to assess PSME2 expression. A dextran sulfate sodium-induced colitis mouse model was employed to evaluate disease progression, colon histology, and PSME2 levels.

Indexed as

autophagyintestinal barrier functionpro-inflammatory cytokinesPSME2ulcerative colitis

Identifiers

PMID41211066
PMCPMC12596035

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.