Evidence map›Paper›PMID 41210990›Full record

ArticleiScience2025

Dual-action thioarylamide-based small molecules to target drug-resistant bacteria and chronic inflammation.

Maria De Fenza, Rosa Gaglione, Alice Rossi, Marco Campanile, Angela Cesaro, Davide Gugliandolo, Ida De Fino, Marco Chino, Luigi Petraccone, Angelina Lombardi and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Maria De FenzaDepartment of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.
Rosa GaglioneDepartment of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.
Alice RossiInfections and Cystic Fibrosis Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milano, Italy.
Marco CampanileDepartment of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.
Angela CesaroDepartment of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.
Davide GugliandoloInfections and Cystic Fibrosis Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milano, Italy.
Ida De FinoInfections and Cystic Fibrosis Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milano, Italy.
Marco ChinoDepartment of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.
Luigi PetracconeDepartment of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.
Angelina LombardiDepartment of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.
Gerardino D'ErricoDepartment of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.
Alessandra BragonziInfections and Cystic Fibrosis Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milano, Italy.
Angela ArcielloDepartment of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.
Vincenzo PavoneDepartment of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.
Daniele D'AlonzoDepartment of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the synthesis and the antibacterial activity of a library of thioarylamide derivatives, which include N-19004, previously developed as Formyl Peptide Receptor 1 antagonist. These compounds were active against a broad spectrum of pathogens, including clinical strains of

Indexed as

BiochemistryBiological sciencesMicrobiologyNatural sciences

Identifiers

PMID41210990
PMCPMC12590031

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.