Evidence map›Paper›PMID 41210989›Full record

ArticleiScience2025

Down-regulation of MFNG promotes the metastatic potential of lung adenocarcinoma by regulating TGF-β/Smad signaling.

Tianshu Miao, Yilin Zhang, Feng Tian, Xiaoying Xu, Qin Wei, Xiaoyu Jiang, Lijuan Ma, Pengju Zhang, Fengzhe Chen, Xiaoyan Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tianshu MiaoKey Laboratory Experimental Teratology of the Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.
Yilin ZhangKey Laboratory Experimental Teratology of the Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.
Feng TianDepartment of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China.
Xiaoying XuDepartment of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China.
Qin WeiKey Laboratory Experimental Teratology of the Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.
Xiaoyu JiangKey Laboratory Experimental Teratology of the Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.
Lijuan MaKey Laboratory Experimental Teratology of the Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.
Pengju ZhangKey Laboratory Experimental Teratology of the Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.
Fengzhe ChenDepartment of Infectious Disease, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250013, China.
Xiaoyan LinDepartment of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Manic Fringe (MFNG), a fucose-specific β-1,3-N-acetylglucosaminyltransferase, is critically involved in different cancers. However, the potential role and underlying mechanism of MFNG in the progression of lung adenocarcinoma (LUAD) remain unclear. Here, we found that MFNG was significantly down-regulated in LUAD tissues compared with adjacent non-cancerous tissues. Moreover, its decreased expression was associated with aggressive LUAD characteristics, including high grade and poor prognosis. Functional studies revealed that MFNG deficiency promoted migratory and invasive capabilities as well as the epithelial-mesenchymal transition of LUAD cells

Indexed as

Biological sciencesCancerGlycobiology

Identifiers

PMID41210989
PMCPMC12590482

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.