Evidence map›Paper›PMID 41210987›Full record

ArticleiScience2025

Ancient genomes reveal basal Asian ancestries and dynamic population interactions over time on the southern Tibetan Plateau.

Jingkun Ran, Yichen Liu, Shargan Wangdue, Xiaoyan Yang, Tianyi Wang, Yu Gao, Peng Cao, Yan Tong, Qingyan Dai, Songtao Chen and 6 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jingkun RanGroup of Alpine Paleoecology and Human Adaptation (ALPHA), State Key Laboratory of Tibetan Plateau Earth System, Resources and Environment (TPESRE), Institute of Tibetan Plateau Research, Chinese Academy of Sciences, Beijing, China.
Yichen LiuKey Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing, China.
Shargan WangdueTibetan Institute of the Preservation of Cultural Relics, Lhasa, China.
Xiaoyan YangKey Scientific Research Base of Bioarchaeology in Cold and Arid Regions (National Cultural Heritage Administration), College of Earth and Environmental Sciences, Lanzhou University, Lanzhou, China.
Tianyi WangKey Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing, China.
Yu GaoGroup of Alpine Paleoecology and Human Adaptation (ALPHA), State Key Laboratory of Tibetan Plateau Earth System, Resources and Environment (TPESRE), Institute of Tibetan Plateau Research, Chinese Academy of Sciences, Beijing, China.
Peng CaoKey Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing, China.
Yan TongTibetan Institute of the Preservation of Cultural Relics, Lhasa, China.
Qingyan DaiKey Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing, China.
Songtao ChenNational Centre for Archaeology, Beijing, China.
Han ShiKey Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing, China.
Feng LiuKey Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing, China.
Xiaotian FengKey Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing, China.
Yazhong LiTibetan Institute of the Preservation of Cultural Relics, Lhasa, China.
Fahu ChenGroup of Alpine Paleoecology and Human Adaptation (ALPHA), State Key Laboratory of Tibetan Plateau Earth System, Resources and Environment (TPESRE), Institute of Tibetan Plateau Research, Chinese Academy of Sciences, Beijing, China.
Qiaomei FuKey Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The southern Tibetan Plateau is a key region for the settlement and flourishing of Tibetan populations, but the long-term population dynamics in this area remain poorly understood. By analyzing 16 newly sequenced genomes from the Mabu Co site (4400 masl), we reconstructed the population history on the southern Tibetan Plateau spanning 4,400-3,500 BP. While the local southern plateau ancestry was maintained over a millennium, genetic diversity within these populations was observed over time. We revealed multiple admixtures, including Basal Asian Xingyi-related ancestry linked to hunter-gatherer populations from southwestern China, and provided the first evidence of this ancestry influencing the ancient southern Tibetan Plateau populations again after 4,000 BP. Moreover, mtDNA and Y haplogroups reveal that individuals exhibit greater maternal genetic diversity alongside restricted paternal lineage conservation. This study provides a higher-resolution population history in the ultra-highlands, contributing to understanding human adaptation to extreme environments.

Indexed as

GenomicsHuman geographyPaleogeneticsPopulation

Identifiers

PMID41210987
PMCPMC12589885

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