Evidence map›Paper›PMID 41210983›Full record

ArticleiScience2025

BPAG1 promotes osteoclastogenesis and postmenopausal osteoporosis via activating ERK signaling pathway.

Yufeng Zhang, Han Zheng, Li Yang, Yi Wang, Liang Zhang

Abstract read
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Extracellular vesicle-mediated crosstalk in bone: miR-150-5p as a mechanosensitive regulator of osteoclastogenesis.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yufeng ZhangDepartment of Orthopedics, The Second Hospital of Tianjin Medical University, Tianjin 300211, China.
Han ZhengDepartment of Orthopedics, The Second Hospital of Tianjin Medical University, Tianjin 300211, China.
Li YangDepartment of Orthopedics, The Second Hospital of Tianjin Medical University, Tianjin 300211, China.
Yi WangDepartment of Pain Management, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Liang ZhangDepartment of Orthopedics, The Second Hospital of Tianjin Medical University, Tianjin 300211, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoclasts (OCs), as the primary cells responsible for bone resorption, play a crucial role in the development of osteoporosis. Yet, how OC differentiation is regulated and involved in the occurrence of OP remains unknown. Here, we notice that BPAG1 is closely related to OC differentiation and osteoporosis. The upregulation of BPAG1 promotes OC differentiation

Indexed as

biological sciencesmolecular biologyPhysiology

Identifiers

PMID41210983
PMCPMC12590000

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.