Evidence map›Paper›PMID 41210976›Full record

ArticleiScience2025

Single-nucleus RNA sequencing reveals GABAergic vulnerability and reactive gliosis driven by loss of TDP-43.

Rashmi Thapa, Navin Adhikari, Sishir Gautam, Mingming Sun, Sierra McOmie, Viyaleta Davydzenka, Derek Smith, Jack Syring, Harlie Kaligis, Jade Marie Kosmicki and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rashmi ThapaDepartment of Zoology and Physiology, University of Wyoming, 1000 E. University Avenue, Laramie, WY 82071, USA.
Navin AdhikariDepartment of Zoology and Physiology, University of Wyoming, 1000 E. University Avenue, Laramie, WY 82071, USA.
Sishir GautamDepartment of Zoology and Physiology, University of Wyoming, 1000 E. University Avenue, Laramie, WY 82071, USA.
Mingming SunDepartment of Zoology and Physiology, University of Wyoming, 1000 E. University Avenue, Laramie, WY 82071, USA.
Sierra McOmieDepartment of Zoology and Physiology, University of Wyoming, 1000 E. University Avenue, Laramie, WY 82071, USA.
Viyaleta DavydzenkaDepartment of Zoology and Physiology, University of Wyoming, 1000 E. University Avenue, Laramie, WY 82071, USA.
Derek SmithDepartment of Zoology and Physiology, University of Wyoming, 1000 E. University Avenue, Laramie, WY 82071, USA.
Jack SyringDepartment of Zoology and Physiology, University of Wyoming, 1000 E. University Avenue, Laramie, WY 82071, USA.
Harlie KaligisHarvard College, Cambridge, MA 02138, USA.
Jade Marie KosmickiDepartment of Zoology and Physiology, University of Wyoming, 1000 E. University Avenue, Laramie, WY 82071, USA.
Rong ChenDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, 100 N. Greene Street, Baltimore, MD 21201, USA.
Yun LiDepartment of Zoology and Physiology, University of Wyoming, 1000 E. University Avenue, Laramie, WY 82071, USA.

Funding

Zebrafish Models of CNS Injury and Locomotor RecoveryP20GM121310 · NIGMS · UNIVERSITY OF WYOMING · PI Qian-Quan Sun · 2017 to 2026
$27.2M
Loss of TDP-43 disrupts the prefrontal neural activity and circuitry: relevance for TDP-43 linked ADRDR01NS129878 · NINDS · UNIVERSITY OF WYOMING · PI YUN LI, PHILIP C WONG · 2025 to 2026
$1.5M
NIGMS NIH HHS P20 GM121310NINDS NIH HHS R01 NS129878
6 · The paper itself

Abstract

TDP-43 is an RNA-binding protein important for RNA processing, whose loss of function is involved in multiple neurodegenerative disorders, including frontotemporal dementia, amyotrophic lateral sclerosis, and Alzheimer's disease (AD). We performed single-nucleus RNA-sequencing to study the convergent and divergent molecular signatures of short-term and long-term TDP-43 depletion in the medial prefrontal cortex (mPFC) using

Indexed as

neurosciencetranscriptomics

Identifiers

PMID41210976
PMCPMC12595131

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.