Evidence map›Paper›PMID 41210969›Full record

ArticleiScience2025

Systematic and synthetic biology insights into copper homeostasis in Escherichia coli.

Zhiqiang Chen, Yu Fu, Jiajia Li, Jin Wang, Xiaona Fang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhiqiang ChenSchool of Chemistry, Northeast Normal University, Changchun, Jilin 130024, P.R. China.
Yu FuSchool of Chemistry, Northeast Normal University, Changchun, Jilin 130024, P.R. China.
Jiajia LiSchool of Chemistry, Northeast Normal University, Changchun, Jilin 130024, P.R. China.
Jin WangState Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P.R. China.
Xiaona FangSchool of Chemistry, Northeast Normal University, Changchun, Jilin 130024, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Copper serves as an essential trace element in biological systems through its association with metalloenzymes. Two major regulatory systems (cueR and cus) participate in the transcriptional regulation of copper homeostasis genes, yet critical mechanisms remain poorly understood. We systematically investigated E. coli's copper response using systems and synthetic biology approaches, revealing more detailed mechanisms. Our results suggested that the cus system specifically responds to Cu

Indexed as

Biological sciencesMedical MicrobiologyMicrobial metabolismMicrobial physiologyMolecular microbiology

Identifiers

PMID41210969
PMCPMC12589874

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.