ArticleiScience2025
A role for Fas/FasL-dependent NK-mediated cytotoxicity in infants with perinatal HIV.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Natural killer cells in pediatric HIV cure strategies: from viral control to immunotherapeutics.Current opinion in HIV and AIDS · 2026Review
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Authors and funding
8 authors.
Funding
Abstract
Perinatal HIV infection occurs during a critical window of immune system development, yet its impact on innate immune responses in early life remains incompletely understood. This study examined natural killer (NK) cell phenotype, transcriptional profile, and function in infants living with perinatal (pHIV) and HIV-exposed uninfected (pHEU) peers from Mozambique. At pre-ART initiation, NK cells were expanded in pHIV, but overall NK cytotoxic activity appeared similar between groups. A key finding was the identification of the Fas/FasL pathway as a preferred mechanism for the NK cell-mediated killing of HIV-infected cells, while perforin-dependent killing was preferred in response to the highly NK sensitive K562 cell line. Infants with higher viral loads exhibited reduced
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