Evidence map›Paper›PMID 41210961›Full record

ArticleiScience2025

Mapping atherogenesis mechanisms in smooth muscle cells by targeting genes linked to coronary artery disease.

Julián Albarrán-Juárez, Anton Markov, Anne Louise Jensen, Peter Loof Møller, Anna Katarzyna Uryga, Djordje Djordjevic, Jakob Hansen, Lise Filt Jensen, Diana Sharysh, Charles Pyke and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Julián Albarrán-JuárezDepartment of Clinical Medicine, Aarhus University, 8200 Aarhus, Denmark.
Anton MarkovDepartment of Clinical Medicine, Aarhus University, 8200 Aarhus, Denmark.
Anne Louise JensenDepartment of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
Peter Loof MøllerDepartment of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
Anna Katarzyna UrygaDepartment of Cardiovascular Biology, Research & Early Development, Novo Nordisk A/S, 2760 Copenhagen, Denmark.
Djordje DjordjevicDepartment of Computational Biology, Novo Nordisk A/S, 2760 Copenhagen, Denmark.
Jakob HansenDepartment of Clinical Medicine, Aarhus University, 8200 Aarhus, Denmark.
Lise Filt JensenDepartment of Clinical Medicine, Aarhus University, 8200 Aarhus, Denmark.
Diana SharyshDepartment of Clinical Medicine, Aarhus University, 8200 Aarhus, Denmark.
Charles PykeDepartment of Computational Biology, Novo Nordisk A/S, 2760 Copenhagen, Denmark.
Jaime MorenoDepartment of Computational Biology, Novo Nordisk A/S, 2760 Copenhagen, Denmark.
Giulia BorghettiDepartment of Cardiovascular Biology, Research & Early Development, Novo Nordisk A/S, 2760 Copenhagen, Denmark.
Julian BachmannDepartment of Cardiovascular Biology, Research & Early Development, Novo Nordisk A/S, 2760 Copenhagen, Denmark.
Kate HerumDepartment of Cardiovascular Biology, Research & Early Development, Novo Nordisk A/S, 2760 Copenhagen, Denmark.
Lisa Maria RøgeDepartment of Clinical Medicine, Aarhus University, 8200 Aarhus, Denmark.
Matthew TraylorDepartment of Genetics, Novo Nordisk A/S, Research Centre Oxford, OX3 7FZ Oxford, UK.
Michael NybergDepartment of Cardiovascular Biology, Research & Early Development, Novo Nordisk A/S, 2760 Copenhagen, Denmark.
Mette NyegaardDepartment of Health Science and Technology, Aalborg University, 9000 Aalborg, Denmark.
Jacob Fog BentzonDepartment of Clinical Medicine, Aarhus University, 8200 Aarhus, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genome-wide association studies (GWASs) have linked numerous genetic loci active in vascular cells to coronary artery disease (CAD), implicating smooth muscle cells (SMCs) and SMC-derived mesenchymal cells as potential mediators. We combined CAD GWAS with single-cell RNA sequencing (scRNA-seq) from human atherosclerotic plaques to identify 20 risk genes with putative action in SMCs, and then performed

Indexed as

cardiovascular medicinegenomics

Identifiers

PMID41210961
PMCPMC12589888

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.