ReviewiScience2025
Angiopoietin-like protein 7: A narrative review and its potential roles in post-myocardial infarction fibrosis.
Review in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Exploring a plasma proteomic biosignature associated with cardiac involvement in Fabry disease.Journal of molecular medicine (Berlin, Germany) · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Angiopoietin-like protein 7 (ANGPTL7) is a secreted protein involved in tissue remodeling and fibrosis, playing roles in various pathological processes such as glaucoma, metabolic disorders, and cancer. Current research has found that ANGPTL7 plays a role in various diseases, including tumors, metabolic disorders, and glaucoma. In recent years, its potential functions in the cardiovascular system have begun to be preliminarily explored. Research suggests that ANGPTL7 expression levels may be associated with the pathological progression of atherosclerosis and hypertension, and it has shown potential as a prognostic biomarker in acute heart failure. Given its known pro-fibrotic biological functions and emerging links to cardiovascular pathology, this review first comprehensively integrates the molecular mechanisms and functions of ANGPTL7 across various disease contexts, with a primary focus on its roles in the cardiovascular system. Building on this foundation, this review further constructs and explores a comprehensive hypothesis regarding its potential role in pathological fibrosis following myocardial infarction. A deeper understanding of ANGPTL7 could offer a novel therapeutic strategy to mitigate cardiac fibrosis and, ultimately, prevent heart failure.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.