Evidence map›Paper›PMID 41210948›Full record

ArticleFrontiers in cellular and infection microbiology2025

Benzyl isothiocyanate exhibits antibacterial and antibiofilm activity against

Abdulaziz A Almobarak, Abdullah Alqedairi, Abdulaziz Binrayes, Rhodanne A Lambarte, Abdurahman A Niazy, Fahd Aljarbou

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Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Abdulaziz A AlmobarakDepartment of Restorative Dental Sciences, Endodontic Division, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
Abdullah AlqedairiDepartment of Restorative Dental Sciences, Endodontic Division, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
Abdulaziz BinrayesDepartment of Prosthetic Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
Rhodanne A LambarteMolecular and Cell Biology Laboratory, Prince Naif bin Abdulaziz Health Research Center, King Saud University Medical City, Riyadh, Saudi Arabia.
Abdurahman A NiazyMolecular and Cell Biology Laboratory, Prince Naif bin Abdulaziz Health Research Center, King Saud University Medical City, Riyadh, Saudi Arabia.
Fahd AljarbouDepartment of Restorative Dental Sciences, Endodontic Division, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Regenerative endodontic procedures require effective disinfection and preservation of stem cell viability, which are essential for successful tissue regeneration. Conventional intracanal medicaments possess antibacterial properties but may negatively impact stem cell survival. Benzyl isothiocyanate (BITC) is a bioactive compound with known antibacterial properties and favorable biocompatibility. Methods: This study evaluated the antibacterial efficacy of BITC against Results: BITC exhibited MIC and MBC values of 0.2% and 0.4%, respectively. At 0.2%, BITC demonstrated comparable antibacterial activity to Ca(OH) Conclusion: These findings suggest that BITC could serve as a potential antimicrobial agent in regenerative endodontic treatment and future therapeutic applications.

Indexed as

Anti-Bacterial AgentsBiofilmsFusobacterium nucleatumIsothiocyanatesMesenchymal Stem CellsCalcium HydroxideCells, CulturedCell SurvivalHumansMicrobial Sensitivity TestsMicrobial ViabilityAnti-Bacterial Agentsbenzyl isothiocyanateCalcium HydroxideIsothiocyanatesantibiofilmantimicrobialbenzyl isothiocyanatecalcium hydroxideFusobacterium nucleatumregenerative endodonticsstem cellsviability

Identifiers

PMID41210948
PMCPMC12592193

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.