ArticleACS omega2025
Microneedle-Integrated Screen-Printed Electrode Modified with Gold Nanoparticle-Boron-Doped Diamond Nanoparticle Nanocomposites for Electrochemical Theophylline Detection.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Rethinking asthma therapy, part 2: transdermal strategies for adjunct asthma and allergy treatments.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2026Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Theophylline is a drug with a narrow therapeutic index, with normal plasma levels ranging from 10 to 20 mg/L. Theophylline overdose can lead to several symptoms, including nausea, vomiting, headaches, pancreatitis, and death. Thus, it is important to monitor theophylline after its consumption. Microneedles (MNs) can be integrated with screen-printed electrodes (SPE) to enable the minimally invasive monitoring of theophylline. In this study, we developed a highly sensitive and accurate electrochemical sensor to detect theophylline based on a gold nanoparticle/boron-doped diamond nanoparticle nanocomposite-modified SPE (AuNP-BDDNP/SPE). In addition, this study aims to determine the feasibility of MN integration with AuNP-BDDNP/SPE for theophylline detection. UV-vis, TEM, and XPS confirmed the successful synthesis of AuNP-BDDNP, whereas FESEM images confirmed the successful modification of SPE. Theophylline detection was performed using differential pulse voltammetry (DPV) with concentrations ranging from 20 to 140 μM, producing an
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Registered trials
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