Evidence map›Paper›PMID 41210725›Full record

ArticleACS omega2025

Chemical Genetics with SP600125 Reveals That Mps1 Protein Kinase Works as a Regulatory Element in Post-embryonic Development of the

Emanuel Victor Nogueira Gotardo, Eduardo Alves Gamosa de Oliveira, Lucas Zanchetta Passamani, Izabela Silva Dos Santos, Geraldo de Amaral Gravina, Claudete Santa-Catarina, Vanildo Silveira, Antônia Elenir Amâncio Oliveira, Marco Antonio Lopes Cruz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Emanuel Victor Nogueira GotardoLaboratório de Biotecnologia Vegetal, Universidade Federal do Rio de Janeiro, Av. Amaro Reinaldo dos Santos Silva, 764, São José do Barreto, Macaé, Rio de Janeiro 27965-045, Brazil.ORCID https://orcid.org/0009-0004-4864-6772
Eduardo Alves Gamosa de OliveiraLaboratório de Química de Função de Proteínas e Peptídeos, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Av. Alberto Lamego 2000, P5, sala 224, Campos dos Goytacazes 28013-602, Brazil.
Lucas Zanchetta PassamaniLaboratório de Biotecnologia, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Av. Alberto Lamego 2000, Campos dos Goytacazes 28013-602, Brazil.
Izabela Silva Dos SantosLaboratório de Biotecnologia Vegetal, Universidade Federal do Rio de Janeiro, Av. Amaro Reinaldo dos Santos Silva, 764, São José do Barreto, Macaé, Rio de Janeiro 27965-045, Brazil.
Geraldo de Amaral GravinaLaboratório de Engenharia Agrícola, Centro de Ciências e Tecnologias Agropecuárias, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Av. Alberto Lamego 2000, Campos dos Goytacazes 28013-602, Brazil.
Claudete Santa-CatarinaLaboratório de Biologia Celular e Tecidual, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Av. Alberto Lamego, 2000, Campos dos Goytacazes 28013-602, Brazil.ORCID https://orcid.org/0000-0002-1669-660X
Vanildo SilveiraLaboratório de Biotecnologia, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Av. Alberto Lamego 2000, Campos dos Goytacazes 28013-602, Brazil.ORCID https://orcid.org/0000-0001-5697-6932
Antônia Elenir Amâncio OliveiraLaboratório de Química de Função de Proteínas e Peptídeos, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Av. Alberto Lamego 2000, P5, sala 224, Campos dos Goytacazes 28013-602, Brazil.ORCID https://orcid.org/0000-0002-2618-8916
Marco Antonio Lopes CruzLaboratório de Biotecnologia Vegetal, Universidade Federal do Rio de Janeiro, Av. Amaro Reinaldo dos Santos Silva, 764, São José do Barreto, Macaé, Rio de Janeiro 27965-045, Brazil.ORCID https://orcid.org/0000-0002-3013-657X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The "spindle assembly checkpoint" (SAC) is a regulatory pathway that monitors the correct anchoring of the mitotic spindle microtubules to chromosomes during the metaphase-anaphase transition. The protein kinase monopolar spindle 1 (Mps1) is a key SAC component and is considered a promising target for antitumor drugs. This has led to the development of different inhibitory molecules that have helped to elucidate the Mps1 functions in the cell cycle. However, in plants, the catalytic mechanisms and roles of Mps1 during cell proliferation remain unknown. Here, we show that

Identifiers

PMID41210725
PMCPMC12593080

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.