ArticlePNAS nexus2025
Conservation of glial density and cell-type ratios within a brain region across mammals.
Article in PNAS nexus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- SMURF: soft-segmentation for single-cell reconstruction and topological analysis of spatial transcriptomic data.Nature communications · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glial cells in the brain are as numerous as neurons, but their organization is less understood. One view suggests that glial organization is similar across brain regions. To better understand glial organization, we examined functionally and architecturally diverse neural circuits in humans, other primates, carnivores, and rodents using histology and single nucleus RNA sequencing datasets. We focused on microglia, oligodendrocytes, and astrocytes, which constitute the major glial cell types. Across mammals, while glial volume densities and proportions of glial cell types are preserved within a region, they vary across regions in the brain, suggesting that glial organization is not uniform but circuit-dependent. Additionally, the ratio of glia to neurons increases with brain volume according to a
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Registered trials
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