ArticlePNAS nexus2025
Functional MRI detection of blood-oxygenation-level-dependent responses in both white and gray matter of the spinal cord after optogenetic cortical stimulation.
Article in PNAS nexus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
We report the first demonstrations of neural activity detected using functional MRI within both the gray and white matters of the cervical spinal cord of nonhuman primates in response to stimulation by optogenetic excitation of brain cortex. The right secondary somatosensory cortices (S2) of two squirrel monkeys were transfected with Adeno-associated virus that introduced a light-sensitive cation channel (ChR2) into neurons. An optical fiber was inserted to selectively activate excitatory neurons in S2 targets using a blue laser. MRIs were acquired of the brain and cervical spine at 9.4 Tesla before, during, and after optical excitation. Robust blood-oxygenation-level-dependent (BOLD) signal changes (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.