ReviewProceedings (Baylor University. Medical Center)2025
Reduced-dose versus full-dose direct oral anticoagulants in extended treatment of venous thromboembolism: a systematic review and meta-analysis of randomized controlled trials.
Review in Proceedings (Baylor University. Medical Center), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and Safety of Direct Oral Anticoagulants in Extended Venous Thromboembolism: A Placebo-Controlled Grade Assessed Meta-Analysis.Critical pathways in cardiology · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Venous thromboembolism (VTE) poses a significant clinical burden, ranking as the third primary contributor to cardiovascular-related mortality. While extended anticoagulation reduces recurrence, it raises bleeding risks. Reduced-dose direct oral anticoagulants (DOACs) may offer an optimal balance by preventing VTE recurrence while minimizing hemorrhage. This meta-analysis evaluated the efficacy and safety of reduced-dose DOACs for secondary VTE prevention. Methods: We established a thorough systematic review and meta-analysis of randomized controlled trials from PubMed, Web of Science, Scopus, and Cochrane searches through March 20, 2025. Dichotomous data were pooled utilizing risk ratio (RR), and continuous data were pooled using mean difference (MD), both with a 95% confidence interval (CI), implemented with R version 4.3. Results: Our analysis included three randomized controlled trials encompassing 8615 patients. Reduced-dose anticoagulation was associated with a statistically significant decrease in the incidence of major bleeding (RR: 0.49 [95% CI: 0.29-0.81]; Conclusion: This meta-analysis demonstrated that reduced-dose DOACs offer an effective approach for extended VTE prophylaxis, significantly reducing major bleeding risks without compromising protection against recurrent thrombosis. Notably, the data indicate a potential mortality benefit, solidifying their role in long-term management. These findings advocate for individualized therapy tailored to patient risk profiles, prioritizing an optimal efficacy-safety balance. Further large-scale randomized controlled trials are needed to validate long-term outcomes, refine dosing strategies, and define patient subgroups that derive the maximal benefit.
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Registered trials
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