Evidence map›Paper›PMID 41210547›Full record

ArticleIndian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine2025

Performance of Trigger Tools in Identifying Adverse Drug Events in Emergency Intensive Care Unit: A Prospective Observational Study.

Nandini Prakash, Adusumilli P Kumar, Aruna C Ramesh, Dharini Boopathi, M Deepalakshmi

Abstract read
In one paragraph

Article in Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nandini PrakashDepartment of Pharmacy Practice, MS Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India.ORCID https://orcid.org/0009-0007-8674-4308
Adusumilli P KumarDepartment of Accident and Emergency, Ramaiah Memorial Hospital, Bengaluru, Karnataka, India.ORCID https://orcid.org/0009-0009-6043-3776
Aruna C RameshDepartment of Accident and Emergency, Ramaiah Memorial Hospital, Bengaluru, Karnataka, India.ORCID https://orcid.org/0000-0002-1277-2791
Dharini BoopathiAdverse Reaction Monitoring Centre, Karpagam Faculty of Medical Sciences and Research, Coimbatore, Tamil Nadu, India.ORCID https://orcid.org/0009-0006-6597-5740
M DeepalakshmiDepartment of Pharmacy Practice, JSS College of Pharmacy, Ooty, Tamil Nadu, India.ORCID https://orcid.org/0000-0002-5270-3360

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: To investigate how well trigger tools function while evaluating adverse drug reactions (ADRs) among patients in emergency intensive care units (EICUs) and to assess the sensitivity of the Institute for Healthcare Improvement: Global Trigger Tool (IHI: GTT) for reporting adverse drug events among patients admitted to EICUs. Methods: A prospective, continuous, single-center research study was conducted for 9 months in the Department of Accident and Emergency Medicine. Triggers were defined based on the IHI GTT and Menat trigger tool. Each flagged case was reviewed for 15 minutes, which provides an equitable balance between efficiency and thoroughness to confirm the presence of an ADR. Performance metrics were calculated and analyzed. Results: Three hundred medical records were collected, and 167 cases were randomly analyzed using 87 triggers. The prevalence of ADRs was 28%. The trigger tools showed 83.8% sensitivity and 48.7% specificity. The results indicated that the negative predictive value was 92.3%, while the positive predictive value was 72.9%. Conclusion: Trigger tools are a useful way to identify ADRs, even though issues with specificity and false positives still exist. Further improvements in technology and ongoing development will probably make these instruments even more effective and efficient in the dynamic environment of EICUs. How to cite this article: Prakash N, Kumar AP, Ramesh AC, Boopathi D, Deepalaksmi M. Performance of Trigger Tools in Identifying Adverse Drug Events in Emergency Intensive Care Unit: A Prospective Observational Study. Indian J Crit Care Med 2025;29(10):861-864.

Indexed as

Adverse drug reactionInstitute for Healthcare Improvement: Global Trigger ToolPharmacovigilanceTrigger tool

Identifiers

PMID41210547
PMCPMC12592953

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.