ArticleIndian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine2025
Timing of Vasopressin Initiation in Patients with Septic Shock: An Updated Systematic Review and Meta-analysis with Trial Sequential Analysis.
Article in Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Does Renal Sympathetic Denervation Impact the Outcome in Sepsis-Induced Shock? An Experimental Porcine Model.Journal of clinical medicine · 2026Article
- Severity-stratified vasopressor-escalation strategies in septic shock: a cross-fitted doubly robust analysis with external replication.Frontiers in pharmacology · 2026Article
- Timing Matters: Caution and Opportunity in Early Vasopressin for Septic Shock.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
- Author Response: Timing Matters: Caution and Opportunity in Early Vasopressin for Septic Shock.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
- Early Vasopressin in Septic Shock-Promise, Paradox, and the Pursuit of Precision.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
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Authors and funding
6 authors.
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Abstract
Background and aims: We performed this systematic review and meta-analysis to study the timing of vasopressin initiation and its association with patient-centered outcomes in adult patients with septic shock. Data sources and study selection: We searched Embase, PubMed, and Web of Science for eligible prospective, retrospective studies, and Randomized controlled trials (RCTs) from January 2013 to December 2024 in adult patients with septic shock that compared an early (<6 hours) vs late strategy (>6 hours) of vasopressin initiation. Our primary outcome was short-term mortality, while other secondary outcomes included hospital and ICU mortality, incidence of renal replacement therapy (RRT), occurrence of new-onset arrhythmias (NOA), and ICU and hospital length of stay (LOS). Results: Seven studies with a total of 3,993 patients were included in the systematic review and meta-analysis. Early initiation of vasopressin was associated with a lower short-term mortality [relative risk (RR) 0.84, 95% CI: 0.71-0.99; Conclusion: We report a significant advantage of initiating vasopressin within six hours for patients experiencing septic shock. However, the studies contributing to this meta-analysis are characterized as being at high risk of bias. How to cite this article: Bhattacharjee A, Datta PK, Kumar V, Ravikumar RH, Sathe P, Kundu R. Timing of Vasopressin Initiation in Patients with Septic Shock: An Updated Systematic Review and Meta-analysis with Trial Sequential Analysis. Indian J Crit Care Med 2025;29(10):839-850.
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