ArticlePlastic and reconstructive surgery. Global open2025
Outcome of Prepectoral Direct-to-Implant Breast Reconstruction With the Poly-4-hydroxybutyrate Wrap.
Article in Plastic and reconstructive surgery. Global open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Oncologic outcomes after poly-4-hydroxybutyrate scaffold in post-mastectomy breast reconstruction: a retrospective, multi-center cohort study.World journal of surgical oncology · 2026Article
- Surgical Burden of Breast Cancer Treatment: Implications of Mastectomy, Breast Conservation, and Reconstruction Choices.Medicina (Kaunas, Lithuania) · 2026Review
- Breast Implants: Biomaterials, Surfaces, Biocompatibility-A Biomedical Engineering Perspective.Journal of clinical medicine · 2026Review
- Soft Tissue Scaffolds in Breast Reconstruction: Evolution from Acellular Dermal Matrices to Synthetic Polymers.Journal of clinical medicine · 2026Review
- Restoring Symmetry in Challenging Revision Breast Surgery: Outcomes of Pilot Study with Poly-4-Hydroxybutyrate Implant Construct.Plastic and reconstructive surgery. Global open · 2026Article
- Hot Topics in Implant-Based Breast Reconstruction.Journal of clinical medicine · 2025Review
- Microsurgical Strategies in Post-Radiation and Revision Breast Reconstruction: Optimizing Outcomes in High-Risk Patients.Cancers · 2025Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Prepectoral direct-to-implant (DTI) breast reconstruction has gained popularity for reducing postoperative pain, animation deformity, and the number of surgical procedures. However, the limited vascularized tissue overlying the implant presents challenges. This study evaluated mean 18-month outcomes in prepectoral DTI patients using a poly-4-hydroxybutyrate (P4HB) wrap designed to optimize reconstructive results. Methods: We retrospectively reviewed all consecutive patients who underwent prepectoral DTI breast reconstruction with our P4HB-implant construct. Data were collected via chart review. Results: There were 50 patients with 87 breasts included. The mean (± SD) age of patients was 52.7 (± 11.7) years, and the median (interquartile range) body mass index (BMI) was 23 (5) kg/m Conclusions: This is the first study reporting mean 18-month P4HB outcomes in prepectoral DTI breast reconstruction at full hydrolysis. Most patients did not require revisional procedures during the follow-up period, and reoperations were primarily for aesthetic concerns. These findings suggest that P4HB is an effective adjunct for implant stabilization in breast reconstruction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.