Evidence map›Paper›PMID 41210358›Full record

ArticleData in brief2025

Data on the correlation between hemostatic parameters before treatment start, and markers of fibrinolysis during treatment in patients with acute pulmonary embolism, undergoing ultrasound-assisted catheter-directed thrombolysis.

Dominik F Draxler, Justine Brodard, Heidi Ho, Konstantina Chalkou, Charithani B Keragala, Thomas Lillicrap, Dik Heg, Johanna A Kremer Hovinga, Robert L Medcalf, Anne Angelillo-Scherrer and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Data in brief, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dominik F DraxlerDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 20, CH-3010 Bern, Switzerland.
Justine BrodardDepartment of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 18, CH-3010 Bern, Switzerland.
Heidi HoMolecular Neurotrauma and Haemostasis, Australian Centre for Blood Diseases, Monash University Melbourne, 99 Commercial Road, Melbourne VIC 3004, Australia.
Konstantina ChalkouDepartment of Clinical Research, University of Bern, Freiburgstrasse 3, 3000 Bern, Switzerland.
Charithani B KeragalaMolecular Neurotrauma and Haemostasis, Australian Centre for Blood Diseases, Monash University Melbourne, 99 Commercial Road, Melbourne VIC 3004, Australia.
Thomas LillicrapDepartment of Neurology, John Hunter Hospital, 156 Kookaburra Cct, New Lambton Heights NSW 2305, Newcsatle, Australia.
Dik HegDepartment of Clinical Research, University of Bern, Freiburgstrasse 3, 3000 Bern, Switzerland.
Johanna A Kremer HovingaDepartment of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 18, CH-3010 Bern, Switzerland.
Robert L MedcalfMolecular Neurotrauma and Haemostasis, Australian Centre for Blood Diseases, Monash University Melbourne, 99 Commercial Road, Melbourne VIC 3004, Australia.
Anne Angelillo-ScherrerDepartment of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 18, CH-3010 Bern, Switzerland.
Stefan StorteckyDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 20, CH-3010 Bern, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Personalized medicine is nowadays increasingly being used to tailor therapies to the individual needs of patients [1]. We recently demonstrated, that various fibrinolytic parameters, including the plasma-based inducible plasmin-antiplasmin (plap) complex, as well as viscoelastic parameters, predict the individual treatment response in patients with intermediate- or high-risk pulmonary embolism (PE), treated with ultrasound-assisted catheter-directed thrombolysis (USAT) [2]. Markers of fibrinolysis and coagulation were assessed before the start of treatment (t0) and during the 10 - 15-hour infusion of recombinant tissue-type plasminogen activator (rt-PA) (t6). While we have already provided evidence of the predictive value of the assessed parameters for efficacy outcomes, in this article we present data on the correlation between these predictive markers and the endogenous fibrinolytic response during USAT. These data confirm the predictive value of the identified pre-treatment parameters for the endogenous treatment response, which may be important for their potential usefulness in modulating treatment decisions and dose adjustments in USAT for PE in the future.

Indexed as

Catheter-directed thrombolysisFibrinolysisFibrinolytic capacityFibrinolytic potentialPulmonary embolism

Identifiers

PMID41210358
PMCPMC12590285

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.