Evidence map›Paper›PMID 41210352›Full record

ArticleData in brief2025

Water contact angle data and FTIR data of stem cell/tenocyte co-culture-derived secretome releasing electrospun tube; and adhesion data of fully transected and sutured rabbit Achilles tendons three weeks post-operation under application of such a tube.

Julia Rieber, Iris Miescher, Petra Wolint, Gabriella Meier-Bürgisser, Jeroen Grigioni, Jess G Snedeker, Viola Vogel, Pietro Giovanoli, Maurizio Calcagni, Johanna Buschmann

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Article in Data in brief, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Julia RieberDivision of Plastic Surgery and Hand Surgery, University Hospital of Zurich, 8091 Zurich, Switzerland.
Iris MiescherDivision of Plastic Surgery and Hand Surgery, University Hospital of Zurich, 8091 Zurich, Switzerland.
Petra WolintDivision of Plastic Surgery and Hand Surgery, University Hospital of Zurich, 8091 Zurich, Switzerland.
Gabriella Meier-BürgisserDivision of Plastic Surgery and Hand Surgery, University Hospital of Zurich, 8091 Zurich, Switzerland.
Jeroen GrigioniBalgrist University Hospital, University of Zurich, 8008 Zurich, Switzerland.
Jess G SnedekerBalgrist University Hospital, University of Zurich, 8008 Zurich, Switzerland.
Viola VogelLaboratory of Applied Mechanobiology, Department of Health Sciences and Technology, ETH Zurich, 8092 Zurich, Switzerland.
Pietro GiovanoliDivision of Plastic Surgery and Hand Surgery, University Hospital of Zurich, 8091 Zurich, Switzerland.
Maurizio CalcagniDivision of Plastic Surgery and Hand Surgery, University Hospital of Zurich, 8091 Zurich, Switzerland.
Johanna BuschmannDivision of Plastic Surgery and Hand Surgery, University Hospital of Zurich, 8091 Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tendon ruptures may result in unsatisfactory outcomes, even after long rehabilitation programs and careful return to daily activities and sports. One major problem after a tendon rupture is the fibrotic adhesion formation to the adjacent tissue, which hampers proper motion and may end up in a permanent reduced range of motion. Following a cell-free approach, we cultivated rabbit adipose-derived stem cells (ASCs) and rabbit Achilles tenocytes in a ratio of 3:1 and incorporated the secretome harvested from this co-culture into an emulsion electrospun tubular DegraPol® fiber mesh. These tubes were characterized by thestatic and dynamic water contact angles and by FTIR spectra, with a comparison to tubes without secretome incorporation (control). Furthermore, we present adhesion data from an in vivo experiment, where these tubes were implanted around a fully transected rabbit Achilles tendon after suture at 3 weeks post-operation.

Indexed as

Achilles tendonElectrospinningFibrotic adhesionTendon repairTubular implant

Identifiers

PMID41210352
PMCPMC12595120

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.