ReviewFrontiers in cell and developmental biology2025
Linking signaling dynamics and cell fate decisions through single-cell imaging: evidence and challenges.
Review in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Long-term quantification and brief-pulse optogenetic perturbation of nucleocytoplasmic GtaC dynamics during Dictyostelium development.microPublication biology · 2026Article
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Authors and funding
5 authors.
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Abstract
Our ever-growing capacity to observe dynamic processes at the single-cell level has highlighted how cells use complex signaling dynamics to provide adequate responses to intra- and extracellular cues. Specifically, there is increasing evidence that signaling dynamics can be functional in determining cell fate decisions. In this work, we provide an overview of the growing body of evidence supporting this idea across diverse biological contexts-including immune responses, reactions to DNA damage and growth factors, and embryonic development. In doing so, we aim to provide a precise conceptualization of what is meant when we say that signaling dynamics can determine cell fate, a unifying view of the methodologies used to sustain this claim and to identify some of the existing gaps in our mechanistic understanding of this process. We believe that the body of work hereby described strongly supports the importance of considering the temporal dimension of signaling when seeking to understand how cellular responses are regulated.
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Registered trials
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