ArticleFrontiers in pediatrics2025
Clinical outcomes in the era of test and treat among children living with HIV: a retrospective before/after study in Zambia.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Initiating antiretroviral therapy (ART) immediately after diagnosis of HIV infection may reduce morbidity and mortality in children living with HIV (CLHIV), especially when they are retained in HIV care. In Zambia, the retention rate of CLHIV was unknown. The goal of this study was to determine the retention rate and clinical outcomes of implementing a test-and-treat program in children diagnosed with HIV infection. Methods: We conducted a retrospective before/after study in 42 health facilities in 12 districts of the southern region of Zambia. We reviewed case files of CLHIV initiated on ART before the test-and-treat (BTT) policy (1 January 2014 to 31 July 2016; Results: The median age of 984 CLHIV was 60 months (interquartile range [IQR] 22-100) and 52.3% ( Conclusion: Retention was significantly higher among children enrolled in the test-and-treat (ATT) cohort and those on a DTG-based regimen. In contrast, female sex, longer time to ART initiation after HIV diagnosis, and advanced WHO clinical stages were associated with lower odds of retention. However, retention improved as well as clinical outcomes in ATT compared to BTT after 24 months. This study underscores the importance of initiating ART immediately after diagnosis of HIV to enhance retention in HIV care and treatment. Therefore, improving ART retention by enhancing interventions in resource-limited settings can be highly beneficial.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.