Evidence map›Paper›PMID 41210219›Full record

ArticleMedizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V2025

Radiation sensitivity in genetic tumour syndromes and how to test for them.

Luitpold V Distel, Laura S Hildebrand, Lukas C F Kuhlmann, Ramona K G Vogel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Genetic tumor syndromes - It's time for action.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Luitpold V DistelUniversity Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg Department of Radiation Oncology Universitätsstraße 27 91054 Erlangen Germany.ORCID https://orcid.org/0000-0002-8040-3226
Laura S HildebrandUniversity Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg Department of Radiation Oncology Universitätsstraße 27 91054 Erlangen Germany.ORCID https://orcid.org/0000-0002-1522-9591
Lukas C F KuhlmannUniversity Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg Department of Radiation Oncology Universitätsstraße 27 91054 Erlangen Germany.ORCID https://orcid.org/0000-0002-5795-0715
Ramona K G VogelUniversity Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg Department of Radiation Oncology Universitätsstraße 27 91054 Erlangen Germany.ORCID https://orcid.org/0009-0001-9327-7943

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiation therapy is now well tolerated and associated with few side effects. However, people with certain germline genetic variants may be more sensitive to radiation, increasing their risk of experiencing adverse effects from treatment. Increased sensitivity to radiation can be tested in various ways; chromosomal aberrations, which are mutations, are particularly useful for this purpose. Many genetic variants only cause a slight increase in radiation sensitivity such as heterozygous pathogenic variants in the breast cancer risk genes

Indexed as

BRCA;Dose reductionGenetic variantsLate effectsRadiosensitivityRadiotherapyStochastic risks

Identifiers

PMID41210219
PMCPMC12594447

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.