ArticleClinical and translational radiation oncology2026
Patterns of response in head and neck cancer subregions using daily Quantitative MRI from MR-guided radiation therapy.
Article in Clinical and translational radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Multiparametric MRI for Assessing the Tumor Microenvironment in Head and Neck Cancer: A Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- Feasibility of longitudinal relaxation rate mapping with non-Cartesian sampling and compressed sensing on a 1.5 T magnetic resonance linear accelerator.Physics and imaging in radiation oncology · 2026Article
- Technical Development and Implementation of 3D-QALAS on a 1.5T MR-Linac for the Brain: A Prospective R-IDEAL Stage 0/1 Technology Development Report.medRxiv : the preprint server for health sciences · 2026Article
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Authors and funding
7 authors.
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Abstract
Background and Purpose: Quantitative MRI (qMRI) is an emerging technique for characterizing tissue microenvironments. Prior work has shown that daily qMRI during MR-guided radiotherapy (MRgRT) detects differential responses to hypofractionated radiotherapy (RT) in head and neck squamous cell carcinoma (HNSCC) within the primary gross tumor volume (GTVp). This exploratory study investigates whether subregions of HNSCC tumors show distinct qMRI responses to hypofractionated RT using contoured GTVp subregions and voxelwise data. Materials and Methods: Eighteen subjects with advanced HNSCC underwent MRgRT with daily qMRI over 15 fractions (total dose 50, 55, or 60 Gy). Daily intravoxel incoherent motion (IVIM) and relaxometry sequences were acquired on a 1.5 T MR-Linac. Median ADC, D, D*, f, T Results: Significant changes (p < 0.05) were observed in ADC, D, f, T Conclusions: In this exploratory study, qMRI detected spatial heterogeneity in HNSCC. These findings support its potential role in guiding biologically adaptive RT strategies.
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