Evidence map›Paper›PMID 41210183›Full record

ArticleEuropean heart journal open2025

Electrocardiographic P-wave indices and onset of atrial fibrillation and histological fibrosis in a general Japanese population: a prospective cohort analysis of the Hisayama Study.

Akihiro Maezono, Emi Oishi, Takaya Sasaki, Susumu Takase, Satoko Sakata, Jun Hata, Yoshinao Oda, Takanari Kitazono, Kohtaro Abe, Toshiharu Ninomiya

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Akihiro MaezonoDepartment of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, Japan.ORCID https://orcid.org/0009-0002-1334-7671
Emi OishiDepartment of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, Japan.ORCID https://orcid.org/0000-0002-3740-4119
Takaya SasakiDivision of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, 3-25-8, Nishi-Shimbashi, Minato-Ku, Tokyo 105-8461, Japan.ORCID https://orcid.org/0000-0001-9525-2638
Susumu TakaseDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, Japan.ORCID https://orcid.org/0000-0002-3929-0071
Satoko SakataDepartment of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, Japan.ORCID https://orcid.org/0000-0002-6750-5762
Jun HataCenter for Cohort Studies, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, Japan.ORCID https://orcid.org/0000-0003-2698-344X
Yoshinao OdaDepartment of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, Japan.ORCID https://orcid.org/0000-0001-9636-1182
Takanari KitazonoCenter for Cohort Studies, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, Japan.ORCID https://orcid.org/0000-0002-9006-5937
Kohtaro AbeDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, Japan.ORCID https://orcid.org/0000-0003-4131-5423
Toshiharu NinomiyaDepartment of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, Japan.ORCID https://orcid.org/0000-0002-9347-1527

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: P-wave indices (PWIs) are associated with incidence of atrial fibrillation (AF) and extent of left atrial fibrosis. We investigated associations of P-wave duration and P-wave terminal force in V1 (PTFV1) with incidence of AF and extent of atrial fibrosis in a Japanese community. Methods and results: Participants were classified based on P-wave duration in lead II (≥120 and <120 ms) or PTFV1 (≥4000 and <4000 μV*ms). Fibrosis in the left atrial posterior wall was pathologically evaluated in 133 autopsied cases with clinical information. Hazard ratios for AF were estimated using a Cox proportional hazards model. Differences in the extent of left atrial fibrosis between P-wave index categories were tested by analysis of covariance. A total of 2907 community-dwelling individuals aged ≥40 years without prior AF were followed for 10 years. Participants with prolonged P-wave duration or elevated PTFV1 were older and had more cardiovascular risk factors. During follow-up, 140 participants developed AF. Unadjusted incidence rates of AF were significantly higher in participants with P-wave duration ≥120 ms or PTFV1 ≥ 4000 μV*ms than in those with values below these cut-offs (4.6 vs. 10.6, and 4.7 vs. 14.4 per 1000 person-years, respectively; both Conclusion: P-wave duration and PTFV1 are useful indicators for assessing AF risk. Furthermore, prolonged P-wave duration reflects the extent of left atrial fibrosis.

Indexed as

Atrial cardiomyopathyAtrial fibrillationCommunity-based studyElectrocardiographyLeft atrial fibrosisP-wave

Identifiers

PMID41210183
PMCPMC12596143

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.