Evidence map›Paper›PMID 41210178›Full record

ArticlemicroPublication biology2025

The immunoglobulin domain of

Darlene Mendez, Marine Barsegyan, Cheryl Van Buskirk

Abstract read
In one paragraph

Article in microPublication biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Characterization of the Immunoglobulin Domain ofmicroPublication biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Darlene MendezBiology, California State University, Northridge, Northridge, California, United States.
Marine BarsegyanBiology, California State University, Northridge, Northridge, California, United States.
Cheryl Van BuskirkBiology, California State University, Northridge, Northridge, California, United States.

Funding

Exploring the function and shedding of a potential C. elegans NeuregulinR16NS134541 · NINDS · CALIFORNIA STATE UNIVERSITY NORTHRIDGE · PI CHERYL LYNN VAN BUSKIRK · 2023 to 2026
$590k
NINDS NIH HHS R16 NS134541
6 · The paper itself

Abstract

Epidermal Growth Factor (EGF) family ligands mediate signaling events in development and physiology across species. These ligands are transmembrane proteins that undergo ectodomain shedding to release the soluble EGF domain, which mediates interaction with EGF receptors (EGFR). Some EGF ligand ectodomains also contain an immunoglobulin-like domain (IgD), and the function of this domain within Ig-EGFs varies.

Identifiers

PMID41210178
PMCPMC12593006

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.