Evidence map›Paper›PMID 41210166›Full record

ArticleMolecular therapy. Methods & clinical development2025

Therapeutic mRNA delivery of CRISPR-Cas9 to the trabecular meshwork reverses ocular hypertension in myocilin glaucoma.

Sam Yacoub, Balasankara Reddy Kaipa, Linya Li, Sarahi Rios, Ramesh Kasetti, Prabhavathi Maddineni, Abbot F Clark, Gulab S Zode

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sam YacoubDepartment of Pharmacology and Neuroscience and North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
Balasankara Reddy KaipaGavin Herbert Eye Institute-Center for Translational Vision Research, Department of Ophthalmology, Department of Physiology and Biophysics, University of California, Irvine, Irvine School of Medicine, Irvine, CA 92697, USA.
Linya LiGavin Herbert Eye Institute-Center for Translational Vision Research, Department of Ophthalmology, Department of Physiology and Biophysics, University of California, Irvine, Irvine School of Medicine, Irvine, CA 92697, USA.
Sarahi RiosGavin Herbert Eye Institute-Center for Translational Vision Research, Department of Ophthalmology, Department of Physiology and Biophysics, University of California, Irvine, Irvine School of Medicine, Irvine, CA 92697, USA.
Ramesh KasettiDepartment of Pharmacology and Neuroscience and North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
Prabhavathi MaddineniDepartment of Ophthalmology, School of Medicine, University of Missouri, Columbia, MO 65212, USA.
Abbot F ClarkDepartment of Pharmacology and Neuroscience and North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
Gulab S ZodeGavin Herbert Eye Institute-Center for Translational Vision Research, Department of Ophthalmology, Department of Physiology and Biophysics, University of California, Irvine, Irvine School of Medicine, Irvine, CA 92697, USA.

Funding

Crosstalk Between Unfolded Protein Response and Autophagy for the Treatment of GlaucomaR01EY026177 · NEI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI ZODE, GULAB · 2016 to 2025
$3.8M
Impaired TRVP4-eNOS signaling in TM contributes to glaucomaR01EY034238 · NEI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI Swapnil K. Sonkusare, Gulab Zode · 2022 to 2026
$2.2M
Development and characterization of an inducible model for myocilin POAGR21EY034333 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI ZODE, GULAB · 2023 to 2024
$432k
NEI NIH HHS R01 EY026177NEI NIH HHS R01 EY034238NEI NIH HHS R21 EY034333
6 · The paper itself

Abstract

Mutations in the myocilin gene (

Indexed as

Cas9gene editingglaucomajuvenile-onset glaucomaliposomesmouse model of glaucomamRNA deliverymyocilinocular hypertensionprotein misfoldingtrabecular meshwork

Identifiers

PMID41210166
PMCPMC12594927

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.