ArticleCureus2025
Rituximab-Induced Acute Coronary Syndrome.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rituximab is a chimeric monoclonal antibody that selectively targets CD20+ B lymphocytes, making it an effective therapeutic agent in managing diseases where B cells play a critical role in the pathogenesis. The depletion of B lymphocytes is a crucial therapeutic effect in treating both lymphoproliferative disorders and autoimmune diseases. We present the case of an elderly male with splenic marginal zone lymphoma who developed acute chest pain during rituximab chemotherapy infusion, raising suspicion for rituximab-induced acute coronary syndrome (ACS). Despite an initial rise in cardiac biomarkers (troponin T), the electrocardiography showed no significant changes. The chest pain resolved promptly after discontinuing the rituximab infusion. Due to a low platelet count, primary percutaneous coronary intervention (PCI) was not performed, and instead, a computed tomography (CT) coronary angiogram was used to confirm the ACS diagnosis. The patient was treated conservatively, and rituximab therapy was temporarily halted. This case emphasizes the importance of considering the potential cardiotoxic effects of rituximab, particularly in patients with pre-existing cardiovascular risk factors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.