ArticleCureus2025
Stiff-Person Syndrome: A Case Report and Treatment Modalities.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stiff-person syndrome (SPS) is a rare autoimmune neurologic disorder characterized by fluctuating muscle rigidity and painful spasms. It is often refractory to standard therapies such as benzodiazepines, baclofen, and intravenous immunoglobulin (IVIG). We present the case of a 64-year-old African American female with SPS who experienced limited relief from opioids, muscle relaxants, IVIG, and a single intrathecal baclofen dose. Following intramuscular onabotulinumtoxinA (Botox) injections, she reported marked improvement in rigidity, posture, gait, and activities of daily living, with relief lasting approximately three months per session and no significant adverse effects. This case highlights the potential role of Botox as a safe and effective adjunctive therapy in the symptomatic management of SPS, warranting further research into its long-term efficacy and integration into treatment strategies for refractory cases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.