ReviewCureus2025
Efficacy of Generic 2% Chlorhexidine Gluconate in 70% Alcohol Versus ChloraPrep for Preventing Surgical Site Infections in Orthopedic Surgery: A Scoping Review.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Surgical site infections (SSIs) are common in orthopedic procedures, increasing morbidity, mortality, and healthcare costs. ChloraPrep, which is branded 2% chlorhexidine gluconate in 70% isopropyl alcohol, is commonly used intraoperatively as a prepping agent due to its efficacy as an antiseptic agent. Generic/unbranded formulations of 2% chlorhexidine gluconate in 70% isopropyl alcohol have been demonstrated to be as effective as ChloraPrep across other surgical specialties, with the added benefit of lower costs. The aim of this scoping review article was to identify the available evidence base comparing the efficacy of generic/unbranded 2% chlorhexidine in alcohol with ChloraPrep in the prevention of SSIs in orthopedic surgical patients. This review has demonstrated a significant gap in the literature as to whether unbranded 2% chlorhexidine gluconate in 70% isopropyl alcohol is an efficacious alternative to ChloraPrep. Early evidence suggests that generic 2% chlorhexidine in 70% alcohol may effectively reduce infection and bacterial load in orthopedic surgery. Further rigorously designed randomized comparisons are needed to guide practice and procurement.
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