ArticlePerspectives in clinical research
Effectiveness, safety, and cost-effectiveness of fixed-dose combination of montelukast-bilastine versus montelukast-levocetirizine in allergic rhinitis: A prospective, randomized, open-label, parallel-group study.
Article in Perspectives in clinical research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Several fixed-dose combinations (FDCs) have been available for the treatment of allergic rhinitis (AR), of which montelukast and levocetirizine is one of the highly prescribed FDC. The FDC of bilastine with montelukast was approved by the drug controller general of India (DCGI) in March 2020. Due to the availability of limited evidence, the present study was planned to evaluate and compare the effectiveness, safety, and cost-effectiveness of montelukast/bilastine versus montelukast/levocetirizine in relieving symptoms of AR. Methodology: After getting approval from the Institutional Ethics Committee, a prospective, open-label comparative study was conducted from March 2024 to September 2024 at the Research Institute of Central India. Patients of either gender, in the age group of 18-65 years suffering from AR having total nasal symptom score (TNSS) >8 were enrolled. Selected patients were randomly assigned to Group A (montelukast-bilastine) or Group B (montelukast-levocetirizine) for 4 weeks. Results: TNSS score was significantly reduced in Group A ( Conclusion: Montelukast/bilastine and montelukast/levocetirizine are effective in managing AR. However, montelukast/bilastine offers a better safety profile and is more cost-effective, making it a viable option for AR treatment.
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