ArticlePerspectives in clinical research
Unveiling the recent trends: Therapeutic drug monitoring of antiepileptic drugs in Western India's Tertiary Care Hospital.
Article in Perspectives in clinical research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose/Aim: Primary goal of epilepsy management is to completely eradicate the disease without causing much adverse effects. However, physicians are not achieving this despite availability of antiseizure medicines and therapeutic drug monitoring (TDM) services. The objective was to evaluate 3 years' time trend of antiseizure medications (ASMs) use and primarily compare TDM requisitions for older versus newer ASMs. Materials and Methods: This is an analytical, observational time-trend analysis (TTA) of TDM services. The author retrospectively assessed TDM records of 122 statistically computed patients receiving a total of 448 ASMs over 3 years period from January 2019 to December 2021 stored in the department. Results: Significant portion of the sample comprised older ASMs (252 of 448, 56.25% [95% confidence interval 46%-65%]). Comparison between monotherapy and polytherapy showed a statistically significant difference ( Conclusion: TTA of ASMs showed that in between 2019 and 2021, there was rising trend for use of newer ASMs. Overall, TDM requisitions for older drugs were more in number than newer drugs. The majority were treated with >1 ASMs, and seizure control was satisfactory with few ADRs documented.
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