Evidence map›Paper›PMID 41209750›Full record

ReviewJournal of pain research2025

Restorative Neurostimulation for Patients with Mechanical Chronic Low Back Pain and Impaired Neuromuscular Control of the Lumbar Spine | A New Treatment Paradigm.

Christopher J Gilligan, Avinash S Chavda, Johnson S Ho, David W Lee, Meredith Langhorst, Erika T Yih, Marco Amann

Abstract readReview
In one paragraph

Review in Journal of pain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Restorative neurostimulation of the lumbar multifidus muscles improves mobility, strength, pain and disability in patients with mechanical chronic low back pain.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Christopher J GilliganOffice of the Chief Medical Officer, Robert Wood Johnson University Hospital, New Brunswick, NJ, USA.ORCID 0000-0003-4769-9907
Avinash S ChavdaDepartment of Interventional Pain Management, Virtuoso Spine and Joint, Carrollton, TX, USA.
Johnson S HoDepartment of Interventional Pain Management, New Jersey Spine and Orthopedic, West Orange, NJ, USA.ORCID 0009-0003-7659-8512
David W LeeDepartment of Pain Management, Fullerton Orthopedic Surgery Medical Group, Fullerton, CA, USA.
Meredith LanghorstDepartment of Pain Management and Non-Operative Care, OrthoIndy, Indianapolis, IN, USA.
Erika T YihDepartment of Physical Medicine and Rehabilitation, Harvard Medical School and Spaulding Rehabilitation Hospital, Boston, MA, USA.
Marco AmannDepartment of Neurosurgery, Orthopädisches Krankenhaus Schloss Werneck, Werneck, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic low back pain (CLBP) is a symptom of an underlying pathology. There are distinct phenotypes of CLBP, including neuropathic, nociplastic and nociceptive, or mechanical CLBP. We present a comprehensive clinical overview of restorative neurostimulation for refractory, disabling, mechanical CLBP. Impaired neuromuscular control and consequent degeneration of the multifidus muscles are implicated in the development and persistence of mechanical low back pain. Restorative neurostimulation targets these processes and aims to reverse these degenerative changes in the muscles and mechanoreceptor in the muscle spindles and, therefore, restore motor control of the multifidus muscles, playing an important role for functional stability of the lumbar spine. We detail the theory and rationale of the technology as well as appropriate patient identification and current trial evidence in this comprehensive overview of restorative neurostimulation.

Indexed as

arthrogenic muscle inhibitionchronic mechanical low back painmultifidus muscleneuromuscular controlneurostimulationrestorative neurostimulation

Identifiers

PMID41209750
PMCPMC12595940

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.