ArticleFrontiers in microbiology2025
Molecular epidemiology of
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Genomic phylogenetic characterization ofBiosafety and health · 2026Article
- Integrating epidemiology with genomic tracing to uncover concealed transmission networks in a brucellosis outbreak, Shandong, China.Frontiers in cellular and infection microbiology · 2026Article
- Identification and phylogenetic analysis of sevenFrontiers in cellular and infection microbiology · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The recent identification of Methods: We characterized 12 Results: Epidemiological data indicated that infections primarily occurred in middle-aged men with occupational livestock exposure. Molecular typing revealed biovar 3 as the predominant type (91.7%), dominated by MLVA-8 genotype 36 and its corresponding MLVA-11 genotype 72 (66.7%). MLVA-16 distinguished 12 unique genotypes. The phylogeny based on cgSNP classified the strains into clades C1 (11 bv. 3 strains) and C2 (one bv. 1 strain). Within clade C1, nine strains in subclade C1-III exhibited ≤119 SNP differences, eight of which formed a local clonal transmission chain (≤52 SNPs) and shared MLVA-11 genotype 72. Subclade C1-I contained two strains with novel genotypes resulting from variations at the Bruce18 and Bruce43 loci. The sole C2 strain differed by only 3 SNPs from the A19 vaccine strain, suggesting a potential vaccine-related origin. Genetic links were also identified with strains from other Chinese provinces, among them Heilongjiang and Inner Mongolia, as well as from several countries, including Mongolia and Russia. Discussion: These findings revealed a complex epidemiological pattern in Shandong, primarily characterized by local transmission chains with occasional external introductions, provided a scientific basis for targeted brucellosis control strategies.
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