Evidence map›Paper›PMID 41209681›Full record

ArticleMedical devices (Auckland, N.Z.)2025

Passive, Active, or Both-What Hemostats Do Surgeons Choose in the Real World, and Should We Rethink It?

Kristen Knapp, Isabella G Armento, Rhea Parreno, Natalia Peres Martinez, Rory Tippit, John Chovanes

Abstract read
In one paragraph

Article in Medical devices (Auckland, N.Z.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kristen KnappDepartment of Surgery, Cooper University Hospital, Camden, NJ, USA.
Isabella G ArmentoDepartment of Surgery, Cooper University Hospital, Camden, NJ, USA.
Rhea ParrenoBaxter Healthcare Corporation, Deerfield, IL, USA.
Natalia Peres MartinezBaxter Healthcare Corporation, Deerfield, IL, USA.
Rory TippitBaxter Healthcare Corporation, Deerfield, IL, USA.
John ChovanesDepartment of Surgery, Cooper University Hospital, Camden, NJ, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This study evaluates the association between the type of topical haemostatic agents used during surgery-categorized as active, passive, or a combination of both-and their relationship with intraoperative blood loss and bleeding-related postoperative outcomes. Methods: A retrospective analysis was conducted at Results: A total of 149 patients were included in the analysis: 51 treated with passive agents, 51 with active agents, and 47 with both. The mean age at admission was 55.9 years (SD ±16.3). General surgery was the most frequently represented specialty (24.8%), followed by spine (22.1%), neurosurgery (16.8%), and solid organ procedures (16.1%). The combination group showed the highest estimated blood loss (EBL) at 521.3 mL (SD ±1456.83; 95% CI: 93.5-949.0), compared to 390.7 mL (SD ±1004.81; CI: 108.1-673.3) in the active group and 301.5 mL (SD ±295.78; CI: 218.3-384.7) in the passive group. However, ANCOVA results showed no statistically significant difference in adjusted mean EBL between groups (p = 0.309). Notably, patients in the combination group experienced longer operative times, extended ICU stays, and higher mortality. Conclusion: Numerical trends suggest greater bleeding and more complex postoperative courses in patients treated with the combination of active and passive haemostats. The use of standardized, validated measures of intraoperative bleeding, paired with a strategic approach that anticipates and manages bleeding complications, may support improved clinical outcomes.

Indexed as

bleedinghemostasishemostatpatient blood managementtrauma surgery

Identifiers

PMID41209681
PMCPMC12595961

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.