Evidence map›Paper›PMID 41209571›Full record

ArticleInternational journal of medical sciences2025

Molecular mechanisms and biomarkers of total parenteral nutrition-induced hepatotoxicity revealed by iTRAQ proteomics analysis.

Yung-Yu Hsieh, Jai-Jen Tsai, Shui-Yi Tung, Ko-Chao Lee, Kung-Chuan Cheng, Kam-Fai Lee, Meng-Chiao Hsieh, Cheng-Yi Huang, Chih-Chuan Teng, Chien-Heng Shen and 1 more

Abstract read
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Article in International journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yung-Yu HsiehDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chiayi 613016, Taiwan.
Jai-Jen TsaiSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Shui-Yi TungDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chiayi 613016, Taiwan.
Ko-Chao LeeDivision of Colorectal Surgery, Department of Surgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, Taiwan.
Kung-Chuan ChengDivision of Colorectal Surgery, Department of Surgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, Taiwan.
Kam-Fai LeeDepartment of Pathology, Chang Gung Memorial Hospital, Chiayi, Taiwan.
Meng-Chiao HsiehDivision of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan.
Cheng-Yi HuangDivision of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan.
Chih-Chuan TengDepartment of Nursing, Division of Basic Medical Sciences, Chang Gung University of Science and Technology, Chiayi, Taiwan.
Chien-Heng ShenDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chiayi 613016, Taiwan.
Hsing-Chun KuoDepartment of Nursing, Division of Basic Medical Sciences, Chang Gung University of Science and Technology, Chiayi, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Chemical and Drug Induced Liver InjuryParenteral Nutrition, TotalAnimalsApoptosisBiomarkersDisease Models, AnimalEndoplasmic Reticulum StressHepatocytesHumansLiverMaleOxidative StressProteomicsRatsRats, Sprague-DawleyTandem Mass SpectrometryBiomarkersASK1/mTOR/JNK/p38elongation of very long chain fatty acids protein 5 (Elovl5)endoplasmic reticulum stress (ER stress)polypyrimidine tract-binding protein 3 (Ptbp3)total parenteral nutrition (TPN)

Identifiers

PMID41209571
PMCPMC12595309

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.