Trial reportClinical interventions in aging2025
Effect of Different Neuromuscular Electrical Stimulation Modalities on Clinical and Functional Outcomes in Older Adults with Knee Osteoarthritis: A Randomized Controlled Trial.
Trial report in Clinical interventions in aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Current status and research gaps of neuromodulation in the rehabilitation of knee osteoarthritis: a scoping review.Frontiers in neurologyPooled it
- Prospects for Physical Therapy in Rheumatoid Arthritis: Literature Review.Healthcare (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Osteoarthritis (OA) is a chronic degenerative disease characterized by progressive cartilage degeneration, most commonly affecting the knee. Clinical symptoms such as pain, stiffness, and functional limitations significantly impact quality of life. Although neuromuscular electrical stimulation (NMES) is considered a complementary treatment, evidence comparing different waveforms in clinical management remains limited. Objective: To compare the effects of three different NMES waveforms versus a placebo, applied for four weeks, on pain intensity, disability, and other functional outcomes in individuals with knee osteoarthritis (KOA). Methods: A randomized clinical trial with 100 participants equally assigned to four groups: transcutaneous electric nerve stimulation (TENS) (n=25), interferential current (IFC) (n=25), Aussie current (n=25), and placebo (n=25). Primary outcomes were pain intensity, disability, and pressure pain threshold and secondary outcomes included aerobic capacity, gait speed, lower limb strength, functional mobility, superficial knee temperature, stability, and fall risk. Primary and secondary outcomes were assessed before and after four weeks. Results: A significant group x time interaction, with a moderate effect size, was found for the WOMAC index (P = 0.022; η Conclusion: Different NMES protocols did not provide additional benefits over placebo for pain intensity, disability or functional outcomes in people with KOA. These findings highlight the need for further research to refine stimulation protocols and identify patient subgroups that may benefit most from NMES in the management of knee osteoarthritis.
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